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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:79997
Term: GW 4064
Definition: A stilbenoid that has formula C28H22Cl3NO4.
Chemical ID: MESH:C412815
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8multiple interactionsEXP 6480464CTDGW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]; SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]PMID:25496033
MAPK8increases expressionISOMapk8 (Mus musculus)6480464CTDGW 4064 results in increased expression of MAPK8 mRNAPMID:26655953
MAPK8multiple interactionsISOMapk8 (Mus musculus)6480464CTDGW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; GW 4064 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]PMID:25496033
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