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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:7989
Term: pepstatin A
Definition: A pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases.
Chemical ID: MESH:C031375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3multiple interactionsEXP 6480464CTD[aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein] pepstatin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]

PMID:26853465 PMID:31226464
CASP3multiple interactionsISORGD:22756480464CTDpepstatin affects the reaction [thallium nitrate results in increased activity of CASP3 protein] pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein] pepstatin inhibits the reaction [thallium nitrate analog results in increased activity of CASP3 protein]

PMID:22669516 PMID:28378122
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