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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68441
Species: Homo sapiens
RGD Object: Gene
Symbol: GABRE
Name: gamma-aminobutyric acid type A receptor subunit epsilon
Acc ID: CHEBI:7983
Term: pentobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Chemical ID: MESH:D010424
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GABREmultiple interactionsEXP 6480464CTDPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]PMID:10049148
GABREdecreases response to substanceISOGabre (Rattus norvegicus)6480464CTDGABRE protein results in decreased susceptibility to PentobarbitalPMID:9039914
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