Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:79699
Term: Temsirolimus
Definition: A macrolide that has formula C56H87NO16.
Chemical ID: MESH:C401859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1decreases phosphorylationISOEIF4EBP1 (Homo sapiens)6480464CTDtemsirolimus results in decreased phosphorylation of EIF4EBP1 proteinPMID:16033649
Eif4ebp1multiple interactionsISOEIF4EBP1 (Homo sapiens)6480464CTD[sunitinib co-treated with temsirolimus] results in decreased phosphorylation of EIF4EBP1 protein; Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]; temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]PMID:21358348 PMID:22532600
Go Back to source page   Continue to Ontology report