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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3602
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6
Name: ribosomal protein S6
Acc ID: CHEBI:79699
Term: Temsirolimus
Definition: A macrolide that has formula C56H87NO16.
Chemical ID: MESH:C401859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6decreases phosphorylationISORPS6 (Homo sapiens)6480464CTDtemsirolimus results in decreased phosphorylation of RPS6 proteinPMID:16195324 PMID:24392034
Rps6multiple interactionsISORPS6 (Homo sapiens)6480464CTDCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]; temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]PMID:21358348
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