Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:79516
Term: Nonylphenol
Definition: null
Chemical ID: MESH:C025256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDnonylphenol binds to PGR protein

PMID:14579009
decreases activityEXP 6480464CTDnonylphenol results in decreased activity of PGR protein

PMID:17304841
increases expressionEXP 6480464CTDnonylphenol results in increased expression of PGR mRNA, nonylphenol results in increased expression of PGR protein

PMID:20172022
multiple interactionsEXP 6480464CTDnonylphenol inhibits the reaction [Progesterone binds to PGR protein], nonylphenol inhibits the reaction [Progesterone results in increased expression of PGR protein]

PMID:14579009, PMID:18262749
increases expressionISORGD:110926480464CTDnonylphenol analog results in increased expression of PGR mRNA

PMID:25242005
increases expressionISORGD:33176480464CTDnonylphenol results in increased expression of PGR mRNA

PMID:14763995
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.