RGD Gene Chemical Interaction Report

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731081
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	PGR
Name:	progesterone receptor

Acc ID:	CHEBI:79516
Term:	Nonylphenol
Definition:	null
Chemical ID:	MESH:C025256

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects binding	EXP		6480464	CTD	nonylphenol binds to PGR protein	PMID:14579009
decreases activity	EXP		6480464	CTD	nonylphenol results in decreased activity of PGR protein	PMID:17304841
increases expression	EXP		6480464	CTD	nonylphenol results in increased expression of PGR mRNA, nonylphenol results in increased expression of PGR protein	PMID:20172022
multiple interactions	EXP		6480464	CTD	nonylphenol inhibits the reaction [Progesterone binds to PGR protein], nonylphenol inhibits the reaction [Progesterone results in increased expression of PGR protein]	PMID:14579009, PMID:18262749
increases expression	ISO	RGD:11092	6480464	CTD	nonylphenol analog results in increased expression of PGR mRNA	PMID:25242005
increases expression	ISO	RGD:3317	6480464	CTD	nonylphenol results in increased expression of PGR mRNA	PMID:14763995

Go Back to source page

Continue to Ontology report

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description: