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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:79516
Term: Nonylphenol
Definition: null
Chemical ID: MESH:C025256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; nonylphenol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]; nonylphenol inhibits the reaction [IL1A protein results in increased expression of CCL2 mRNA]; nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]; nonylphenol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]PMID:10614622 PMID:36416909
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