GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | diisobutyl phthalate results in increased activity of ESR1 protein | PMID:28571686 | Esr1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ESR1 mRNA | PMID:28013214 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | diisobutyl phthalate binds to and results in increased activity of ESR1 protein; diisobutyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [diisobutyl phthalate binds to and results in increased activity of ESR1 protein] | PMID:15840436 PMID:27633901 PMID:28571686 | | ||||||||||||||||||||||
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