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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:78887
Term: tirapazamine
Definition: A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Chemical ID: MESH:C049947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1multiple interactionsEXP 6480464CTD1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to tirapazamine, Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine], Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine], tempol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

PMID:7710944
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.