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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1increases expressionEXP 6480464CTD2-tert-butylhydroquinone results in increased expression of KEAP1 proteinPMID:31726083
Keap1multiple interactionsEXP 6480464CTD2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein]PMID:31726083
Keap1affects bindingISOKeap1 (Mus musculus)6480464CTD2-tert-butylhydroquinone binds to KEAP1 proteinPMID:19808700
Keap1decreases response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinonePMID:23589329
Keap1increases expressionISOKEAP1 (Homo sapiens)6480464CTD2-tert-butylhydroquinone results in increased expression of KEAP1 proteinPMID:19033392
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTD2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; KEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]PMID:18417180 PMID:23589329
Keap1multiple interactionsISOKeap1 (Mus musculus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased activity of NFE2L2 protein; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]PMID:18512965 PMID:30261176 PMID:31368498 PMID:32073640
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