GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Keap1 | increases expression | EXP | | 6480464 | CTD | 2-tert-butylhydroquinone results in increased expression of KEAP1 protein | PMID:31726083 | Keap1 | multiple interactions | EXP | | 6480464 | CTD | 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein] | PMID:31726083 | Keap1 | affects binding | ISO | Keap1 (Mus musculus) | 6480464 | CTD | 2-tert-butylhydroquinone binds to KEAP1 protein | PMID:19808700 | Keap1 | decreases response to substance | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | KEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone | PMID:23589329 | Keap1 | increases expression | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | 2-tert-butylhydroquinone results in increased expression of KEAP1 protein | PMID:19033392 | Keap1 | multiple interactions | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; KEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein] | PMID:18417180 PMID:23589329 | Keap1 | multiple interactions | ISO | Keap1 (Mus musculus) | 6480464 | CTD | 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased activity of NFE2L2 protein; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]] | PMID:18512965 PMID:30261176 PMID:31368498 PMID:32073640 | |
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