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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTD2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in increased expression of BAX protein]PMID:28583816 PMID:32565124 PMID:37075934
Baxdecreases expressionISOBax (Mus musculus)6480464CTD2-tert-butylhydroquinone results in decreased expression of BAX proteinPMID:22275372
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in decreased expression of BAX proteinPMID:22275372
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]PMID:26878773
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