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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:78870
Term: sodium nitrite
Definition: An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.
Chemical ID: MESH:D012977
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases expressionEXP 6480464CTDSodium Nitrite results in increased expression of HIF1A protein

PMID:28000380, PMID:28266762
Hif1amultiple interactionsEXP 6480464CTDCarnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein], Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]

PMID:28000380, PMID:28266762
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.