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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:78802
Term: diarylheptanoid
Definition: A family of plant metabolites with a common 1,7-diphenylheptane structural skeleton, carrying various substituents. They are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species.
Chemical ID: MESH:D036381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiarylheptanoids results in increased expression of PGR mRNA

PMID:19654927
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of PGR mRNA]

PMID:19654927
affects expressionISORGD:110926480464CTDDiarylheptanoids affects the expression of PGR protein

PMID:23552522
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.