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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:78802
Term: diarylheptanoid
Definition: A family of plant metabolites with a common 1,7-diphenylheptane structural skeleton, carrying various substituents. They are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species.
Chemical ID: MESH:D036381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:692136480464CTDDiarylheptanoids results in increased activity of ESR2 protein

PMID:19654927
multiple interactionsISORGD:692136480464CTDfulvestrant inhibits the reaction [Diarylheptanoids results in increased activity of ESR2 protein]

PMID:19654927
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.