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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62288
Species: Mus musculus
RGD Object: Gene
Symbol: F2
Name: coagulation factor II
Acc ID: CHEBI:78761
Term: ML-7
Definition: An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Chemical ID: MESH:C070571
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2affects activityISOF2 (Homo sapiens)6480464CTDML 7 affects the activity of F2 proteinPMID:1643115
F2affects activityISOF2 (Rattus norvegicus)6480464CTDML 7 affects the activity of F2 proteinPMID:14557824
F2decreases activityISOF2 (Homo sapiens)6480464CTD[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 proteinPMID:16675616
F2multiple interactionsISOF2 (Homo sapiens)6480464CTDML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]PMID:15284075
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