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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68998
Species: Homo sapiens
RGD Object: Gene
Symbol: PENK
Name: proenkephalin
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PENKincreases expressionISOPenk (Rattus norvegicus)6480464CTDOxidopamine results in increased expression of PENK mRNA; Oxidopamine results in increased expression of PENK proteinPMID:12127155 PMID:15065221 PMID:15659429 PMID:17241287 PMID:17329435 PMID:18947822 PMID:19660528 PMID:20456008 PMID:3838946
PENKmultiple interactionsISOPenk (Rattus norvegicus)6480464CTD[Levodopa co-treated with Oxidopamine] results in increased expression of PENK mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNA; [TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]; Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNA]; IEM 1460 inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]; Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA]; Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]; S 33084 inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of PENK mRNA]PMID:15065221 PMID:15659429 PMID:17329435 PMID:18687386 PMID:18947822 PMID:19118628 PMID:20456008
PENKmultiple interactionsISOPenk (Mus musculus)6480464CTD[Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNAPMID:16139809
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