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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62089
Species: Mus musculus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prknmultiple interactionsEXP 6480464CTDPRKN protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]PMID:16914382
Prknaffects expressionISOPRKN (Homo sapiens)6480464CTDOxidopamine affects the expression of PRKN protein alternative formPMID:28688199
Prkndecreases expressionISOPRKN (Homo sapiens)6480464CTDOxidopamine results in decreased expression of PRKN proteinPMID:28688199 PMID:30707903
Prkndecreases reactionISOPRKN (Homo sapiens)6480464CTDPRKN protein inhibits the reaction OxidopaminePMID:15198987
Prknincreases expressionISOPrkn (Rattus norvegicus)6480464CTDOxidopamine results in increased expression of PRKN mRNAPMID:25129099
Prknmultiple interactionsISOPrkn (Rattus norvegicus)6480464CTDisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]PMID:25129099
Prknmultiple interactionsISOPRKN (Homo sapiens)6480464CTDPINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]; Tretinoin affects the reaction [Oxidopamine affects the expression of PRKN protein alternative form]PMID:28688199 PMID:30707903
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