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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732272
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:78695
Term: cantharidic acid
Definition: A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A.
Chemical ID: MESH:C000626960
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDcantharidic acid results in increased phosphorylation of MAPK8 proteinPMID:29345422 PMID:31916385
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