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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2835
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:7864
Term: oxymetholone
Definition: A 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects.
Chemical ID: MESH:D010110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b2decreases activityISORGD:7374686480464CTDOxymetholone results in decreased activity of HSD11B2 protein

PMID:22273746
Hsd11b2multiple interactionsISORGD:7374686480464CTDOxymetholone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]

PMID:22273746
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.