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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735516
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2L1
Name: BCL2 like 1
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2L1decreases expressionEXP 6480464CTDdorsomorphin results in decreased expression of BCL2L1 proteinPMID:31900833
BCL2L1multiple interactionsEXP 6480464CTD[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL2L1 mRNA; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of BCL2L1 protein]; FOXP3 protein inhibits the reaction [dorsomorphin results in decreased expression of BCL2L1 protein]PMID:27188386 PMID:31900833
BCL2L1multiple interactionsISOBcl2l1 (Mus musculus)6480464CTD[dorsomorphin inhibits the reaction [ADIPOQ protein results in increased expression of BCL2L1 protein]] which results in increased activity of CASP3 protein; dorsomorphin inhibits the reaction [ADIPOQ protein results in increased expression of BCL2L1 protein]PMID:20709802
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