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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619569
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC2multiple interactionsISOAbcc2 (Rattus norvegicus)15090804RGDdosomorphin inhibits the reaction [17alpha-ethynylestradiol decreases expression of Abcc2 mRNA in primary hepatocytes and liver lysate] 
ABCC2multiple interactionsISOAbcc2 (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]PMID:36846903
ABCC2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTDdorsomorphin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 protein]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 protein]PMID:27090119 PMID:27702592
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