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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3multiple interactionsISONos3 (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; dorsomorphin inhibits the reaction [Bezafibrate results in increased phosphorylation of NOS3 protein]PMID:21499286
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [Agmatine inhibits the reaction [Palmitic Acid results in increased activity of and results in decreased phosphorylation of NOS3 protein]]; dorsomorphin inhibits the reaction [amurensin G results in increased phosphorylation of NOS3 protein]; dorsomorphin inhibits the reaction [Fenofibrate results in increased activity of NOS3 protein]PMID:20580385 PMID:22982565 PMID:35747990
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