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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1623009
Species: Mus musculus
RGD Object: Gene
Symbol: Tbc1d4
Name: TBC1 domain family, member 4
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbc1d4multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Quercetin inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]]PMID:24343960
Tbc1d4multiple interactionsISOTBC1D4 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D4 mRNAPMID:27188386
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