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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1decreases expressionEXP 6480464CTDdiallyl trisulfide results in decreased expression of GSTP1 mRNA; diallyl trisulfide results in decreased expression of GSTP1 proteinPMID:16344271
GSTP1increases expressionISOGstp1 (Rattus norvegicus)6480464CTDdiallyl trisulfide results in increased expression of GSTP1 mRNAPMID:20237067
GSTP1multiple interactionsISOGstp1 (Rattus norvegicus)6480464CTD[diallyl trisulfide promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [diallyl trisulfide promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; diallyl trisulfide promotes the reaction [JUN protein binds to GSTP1 enhancer]; diallyl trisulfide promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; diallyl trisulfide results in increased expression of and results in increased activity of GSTP1 proteinPMID:20237067
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