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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases activityEXP 6480464CTDdiallyl trisulfide results in increased activity of JUN proteinPMID:20237067
Junincreases expressionEXP 6480464CTDdiallyl trisulfide results in increased expression of JUN proteinPMID:20237067
Junmultiple interactionsEXP 6480464CTD[diallyl trisulfide promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; diallyl trisulfide promotes the reaction [JUN protein binds to GSTP1 enhancer]PMID:20237067
Junaffects localizationISOJUN (Homo sapiens)6480464CTDdiallyl trisulfide affects the localization of JUN proteinPMID:25927362
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDdiallyl trisulfide results in increased phosphorylation of JUN proteinPMID:16707465
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDdiallyl trisulfide inhibits the reaction [TNF protein affects the localization of JUN protein modified form]; MAP2K7 protein affects the reaction [diallyl trisulfide results in increased phosphorylation of JUN protein]PMID:16707465 PMID:35022635
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