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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348437
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP9affects expressionEXP 6480464CTDdiallyl trisulfide affects the expression of MMP9 proteinPMID:21695758
MMP9decreases activityEXP 6480464CTDdiallyl trisulfide results in decreased activity of MMP9 proteinPMID:24084732
MMP9decreases expressionEXP 6480464CTDdiallyl trisulfide results in decreased expression of MMP9 mRNA; diallyl trisulfide results in decreased expression of MMP9 proteinPMID:23430952 PMID:24084732 PMID:25927362 PMID:28741790 PMID:30396169
MMP9multiple interactionsEXP 6480464CTDdiallyl trisulfide results in decreased expression of and results in decreased activity of MMP9 protein; LDHA protein inhibits the reaction [diallyl trisulfide results in decreased expression of MMP9 protein]; NOTCH1 mutant form promotes the reaction [diallyl trisulfide results in decreased activity of MMP9 protein]PMID:23430952 PMID:27566995
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