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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736442
Species: Homo sapiens
RGD Object: Gene
Symbol: PRKCE
Name: protein kinase C epsilon
Acc ID: CHEBI:78373
Term: chelerythrine
Definition: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Chemical ID: MESH:C016299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRKCEmultiple interactionsEXP 6480464CTDchelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein]PMID:21562303
PRKCEmultiple interactionsISOPrkce (Rattus norvegicus)6480464CTD[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to PhenylephrinePMID:12700091
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