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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:78373
Term: chelerythrine
Definition: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Chemical ID: MESH:C016299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDchelerythrine inhibits the reaction [Acids results in increased activity of RELA protein]; chelerythrine inhibits the reaction [Glucose results in increased activity of RELA protein]PMID:12388107 PMID:19074641
Relamultiple interactionsISORela (Mus musculus)6480464CTDchelerythrine inhibits the reaction [Ethanol results in increased expression of RELA protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein]PMID:24300194 PMID:34006824
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