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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735505
Species: Homo sapiens
RGD Object: Gene
Symbol: AQP9
Name: aquaporin 9
Acc ID: CHEBI:78320
Term: 2-hydroxypropanoic acid
Definition: A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Chemical ID: MESH:D019344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AQP9decreases expressionEXP 6480464CTDLactic Acid results in decreased expression of AQP9 mRNAPMID:30851411
AQP9increases uptakeEXP 6480464CTDAQP9 protein results in increased uptake of Lactic AcidPMID:28798983
AQP9multiple interactionsEXP 6480464CTDarsenite inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Nigericin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]PMID:28798983
AQP9increases uptakeISOAqp9 (Rattus norvegicus)6480464CTDAQP9 protein results in increased uptake of Lactic AcidPMID:9733774
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