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Pathways

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2211
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp2
Name: bone morphogenetic protein 2
Acc ID: CHEBI:78277
Term: menaquinone-4
Definition: A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.
Chemical ID: MESH:C030814
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp2increases expressionISOBMP2 (Homo sapiens)6480464CTDmenatetrenone results in increased expression of BMP2 mRNAPMID:31843813
Bmp2increases response to substanceISOBMP2 (Homo sapiens)6480464CTDmenatetrenone results in increased susceptibility to BMP2 proteinPMID:31843813
Bmp2multiple interactionsISOBMP2 (Homo sapiens)6480464CTDCoumestrol inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Coumestrol inhibits the reaction [menatetrenone results in increased expression of BMP2 mRNA]; Coumestrol inhibits the reaction [menatetrenone results in increased susceptibility to BMP2 protein]; Coumestrol inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]; Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]PMID:31843813
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