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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:78067
Term: tin(II) chloride (anhydrous)
Definition: An inorganic chloride that has formula Cl2Sn.
Chemical ID: MESH:C023599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects response to substanceISORGD:7365596480464CTDESR1 protein affects the susceptibility to stannous chloride

PMID:12746304
Esr1decreases expressionISORGD:7365596480464CTDstannous chloride results in decreased expression of ESR1 mRNA, stannous chloride results in decreased expression of ESR1 protein

PMID:12746304
Esr1increases activityISORGD:7365596480464CTDstannous chloride results in increased activity of ESR1 protein

PMID:12746304
Esr1multiple interactionsISORGD:7365596480464CTDstannous chloride inhibits the reaction [Estradiol binds to ESR1 protein]

PMID:12746304
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.