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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:77986
Term: dibenziodolium
Definition: An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Chemical ID: MESH:C007517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDdiphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]PMID:19371610 PMID:25199686
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDdiphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]PMID:11880281 PMID:17384286 PMID:23774252 PMID:31838053
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]PMID:15978937 PMID:16571865 PMID:16632126 PMID:19429262 PMID:19804834 PMID:21391979 PMID:21687637 PMID:21984483 PMID:22142850 PMID:26514923 PMID:30766661 PMID:34890707
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