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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620115
Species: Mus musculus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase, pi 1
Acc ID: CHEBI:77780
Term: sulfaphenazole
Definition: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.
Chemical ID: MESH:D013426
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTDSulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]PMID:24246759
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