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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:77733
Term: 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile
Definition: A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD[Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]PMID:15861398
Casp3increases expressionISOCasp3 (Rattus norvegicus)6480464CTDVerapamil results in increased expression of CASP3 mRNAPMID:19815060
Casp3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDVerapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]PMID:14527821
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Verapamil] results in increased activity of CASP3 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP3 protein; [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]PMID:18358092 PMID:19631781 PMID:19927300 PMID:24373880
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