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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:7772
Term: omeprazole
Definition: A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTD[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]PMID:19251492 PMID:30452898 PMID:32418911
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDOmeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]PMID:30452898
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