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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:7772
Term: omeprazole
Definition: A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDOmeprazole affects the localization of [ARNT protein co-treated with AHR protein]

PMID:9395520
affects localizationISORGD:7327396480464CTDOmeprazole affects the localization of ARNT protein

PMID:25826687
multiple interactionsISORGD:7327396480464CTDOmeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter], Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]

PMID:21703235
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.