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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:77702
Term: S-nitroso-N-acetyl-D-penicillamine
Definition: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.
Chemical ID: MESH:D026423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases expressionISOMapk3 (Rattus norvegicus)6480464CTDS-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK3 proteinPMID:15640287
MAPK3decreases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDS-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 proteinPMID:19252090
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDS-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 proteinPMID:19252090
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein]PMID:19252090
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