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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:7735
Term: olanzapine
Definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Chemical ID: MESH:C076029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1decreases expressionISOCtnnb1 (Mus musculus)6480464CTDolanzapine results in decreased expression of CTNNB1 mRNAPMID:18797397
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDOlanzapine results in increased expression of CTNNB1 mRNAPMID:31563592
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTDOlanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]PMID:31563592
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