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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:7735
Term: olanzapine
Definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Chemical ID: MESH:C076029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1increases expressionEXP 6480464CTDolanzapine results in increased expression of SOD1 mRNAPMID:12752374
Sod1multiple interactionsEXP 6480464CTDolanzapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; olanzapine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]PMID:12752374 PMID:12868070 PMID:16564057
Sod1decreases activityISOSod1 (Mus musculus)6480464CTDOlanzapine results in decreased activity of SOD1 proteinPMID:37019375
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDDietary Fats promotes the reaction [Olanzapine results in decreased activity of SOD1 protein]PMID:37019375
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