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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3702
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a5
Name: solute carrier family 22 member 5
Acc ID: CHEBI:7735
Term: olanzapine
Definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Chemical ID: MESH:C076029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a5decreases expressionISOSlc22a5 (Mus musculus)6480464CTDOlanzapine results in decreased expression of SLC22A5 mRNA; Olanzapine results in decreased expression of SLC22A5 proteinPMID:31437515
Slc22a5multiple interactionsISOSLC22A5 (Homo sapiens)6480464CTDOlanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]PMID:31437515
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