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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:7735
Term: olanzapine
Definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Chemical ID: MESH:C076029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Adecreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDolanzapine results in decreased expression of PPARGC1A mRNAPMID:23226405
PPARGC1Amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTD[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]PMID:23226405
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