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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737448
Species: Mus musculus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases expressionEXP 6480464CTDochratoxin A results in decreased expression of CAT mRNAPMID:28710020
Catmultiple interactionsEXP 6480464CTD[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in decreased expression of CAT mRNAPMID:28710020
Catdecreases activityISOCat (Rattus norvegicus)6480464CTDochratoxin A results in decreased activity of CAT proteinPMID:27923682
Catdecreases activityISOCAT (Homo sapiens)6480464CTDochratoxin A results in decreased activity of CAT proteinPMID:25532488
Catdecreases expressionISOCat (Rattus norvegicus)6480464CTDochratoxin A results in decreased expression of CAT mRNAPMID:12700408
Catincreases expressionISOCAT (Homo sapiens)6480464CTDochratoxin A results in increased expression of CAT mRNAPMID:17316727
Catmultiple interactionsISOCat (Rattus norvegicus)6480464CTD[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]PMID:27923682
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDQuercetin inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]PMID:25532488
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