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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1decreases expressionEXP 6480464CTDochratoxin A results in decreased expression of NQO1 mRNAPMID:30559759
NQO1increases expressionEXP 6480464CTDochratoxin A results in increased expression of NQO1 mRNAPMID:17316727 PMID:30291945
NQO1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDochratoxin A results in decreased expression of NQO1 mRNA; ochratoxin A results in decreased expression of NQO1 proteinPMID:17110534 PMID:19717638
NQO1increases activityISONqo1 (Rattus norvegicus)6480464CTDochratoxin A results in increased activity of NQO1 proteinPMID:25209566
NQO1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of NQO1 protein]PMID:17110534
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