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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects response to substanceEXP 6480464CTDNFE2L2 protein affects the susceptibility to ochratoxin APMID:28710020
Nfe2l2multiple interactionsEXP 6480464CTD[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in decreased expression of CAT mRNA; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in decreased expression of GSR mRNA; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in decreased expression of VEGFA mRNA; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in decreased expression of VEGFA protein; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased abundance of Creatinine; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of BBC3 protein; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of ICAM1 protein; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of TGFB1 protein; [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of TIMP2 mRNA; NFE2L2 protein affects the reaction [ochratoxin A results in decreased expression of TGFB2 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of FN1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of MMP9 protein]; ochratoxin A affects the reaction [NFE2L2 protein affects the expression of HMOX1 mRNA]; ochratoxin A promotes the reaction [NFE2L2 protein affects the expression of BBC3 mRNA]PMID:28710020
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDochratoxin A affects the localization of NFE2L2 proteinPMID:30291945
Nfe2l2decreases activityISONfe2l2 (Rattus norvegicus)6480464CTDochratoxin A results in decreased activity of NFE2L2 proteinPMID:17110534
Nfe2l2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDochratoxin A results in increased expression of NFE2L2 mRNAPMID:24120684
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDochratoxin A results in increased expression of NFE2L2 mRNAPMID:30291945
Nfe2l2increases methylationISONFE2L2 (Homo sapiens)6480464CTDochratoxin A results in increased methylation of NFE2L2 promoterPMID:30559759
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [NFE2L2 protein binds to GSTP1 protein]PMID:17110534
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDAHR protein affects the reaction [ochratoxin A results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of NFE2L2 mRNA]PMID:30291945
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