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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRaffects localizationEXP 6480464CTDochratoxin A affects the localization of AHR proteinPMID:30291945
AHRincreases expressionEXP 6480464CTDochratoxin A results in increased expression of AHR mRNAPMID:21834667 PMID:30291945
AHRmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA]; AHR protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]; AHR protein affects the reaction [ochratoxin A results in increased expression of HMOX1 mRNA]; AHR protein affects the reaction [ochratoxin A results in increased expression of NFE2L2 mRNA]PMID:30291945
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