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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDochratoxin A results in increased expression of MMP9 mRNA; ochratoxin A results in increased expression of MMP9 proteinPMID:16622519 PMID:37162024
Mmp9multiple interactionsEXP 6480464CTDEthanol affects the reaction [ochratoxin A results in increased expression of MMP9 protein]PMID:16622519
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDochratoxin A results in increased expression of MMP9 mRNAPMID:32617660
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDochratoxin A results in increased expression of MMP9 mRNA; ochratoxin A results in increased expression of MMP9 proteinPMID:28710020 PMID:32617660
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDochratoxin A results in increased expression of and results in increased activity of MMP9 proteinPMID:32617660
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [ochratoxin A results in increased expression of MMP9 protein]PMID:28710020
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