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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Muc2
Name: mucin 2, oligomeric mucus/gel-forming
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Muc2multiple interactionsISOMUC2 (Homo sapiens)6480464CTD[Aflatoxin M1 co-treated with ochratoxin A] results in decreased secretion of MUC2 protein; [Aflatoxin M1 co-treated with ochratoxin A] results in increased expression of MUC2 mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC2 mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased secretion of MUC2 proteinPMID:30904571
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