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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDochratoxin A results in increased expression of IL6 mRNAPMID:24792326 PMID:37162024
Il6increases expressionISOIl6 (Mus musculus)6480464CTDochratoxin A results in increased expression of IL6 mRNAPMID:28710020
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDochratoxin A results in increased expression of IL6 mRNA; ochratoxin A results in increased expression of IL6 proteinPMID:25532488 PMID:28286205
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with ochratoxin A] results in increased expression of IL6 protein; [ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of IL6 protein; sulforaphane inhibits the reaction [ochratoxin A results in increased expression of IL6 mRNA]PMID:28710020 PMID:28935500
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [ochratoxin A results in increased expression of IL6 protein]PMID:25532488
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