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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604618
Species: Homo sapiens
RGD Object: Gene
Symbol: CYCS
Name: cytochrome c, somatic
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYCSaffects localizationEXP 6480464CTDochratoxin A affects the localization of CYCS proteinPMID:20549612
CYCSincreases expressionEXP 6480464CTDochratoxin A results in increased expression of CYCS proteinPMID:33465424
CYCSmultiple interactionsEXP 6480464CTDOleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of CYCS protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of CYCS protein]PMID:33465424
CYCSdecreases expressionISOCycs (Rattus norvegicus)6480464CTDochratoxin A results in decreased expression of CYCS mRNAPMID:23358140
CYCSincreases expressionISOCycs (Mus musculus)6480464CTDochratoxin A results in increased expression of CYCS mRNAPMID:36397609
CYCSmultiple interactionsISOCycs (Mus musculus)6480464CTDfumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CYCS mRNA]PMID:36397609
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