Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352552
Species: Homo sapiens
RGD Object: Gene
Symbol: HAVCR1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HAVCR1increases expressionEXP 6480464CTDochratoxin A results in increased expression of HAVCR1 mRNA; ochratoxin A results in increased expression of HAVCR1 proteinPMID:30291945 PMID:31369848
HAVCR1multiple interactionsEXP 6480464CTDAHR protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]; HSPA9 protein affects the reaction [ochratoxin A results in decreased expression of HAVCR1 protein]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]PMID:30291945 PMID:31369848
HAVCR1increases expressionISOHavcr1 (Rattus norvegicus)6480464CTDochratoxin A results in increased expression of HAVCR1; ochratoxin A results in increased expression of HAVCR1 mRNA; ochratoxin A results in increased expression of HAVCR1 proteinPMID:16251485 PMID:18308701 PMID:25218026 PMID:30449730 PMID:31369848
HAVCR1increases secretionISOHavcr1 (Rattus norvegicus)6480464CTDochratoxin A results in increased secretion of HAVCR1 mRNAPMID:18308701
HAVCR1multiple interactionsISOHavcr1 (Mus musculus)6480464CTD[1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of HAVCR1 proteinPMID:36227364
HAVCR1multiple interactionsISOHavcr1 (Rattus norvegicus)6480464CTDHSPA9 protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 protein]PMID:31369848
Go Back to source page   Continue to Ontology report